A2M (alpha-2-macroglobulin)
نویسندگان
چکیده
منابع مشابه
A deletion polymorphism in the human alpha-2-macroglobulin (A2M) gene.
Description: Alpha-2-macroglobulin is a major proteinase inhibitor in man. To study the bait domain, which defines the inhibitory spectrum of the protein and which is encoded by two exons (1), primers were designed to amplify the second exon.
متن کاملHuman Plasma Alpha 2-macroglobulin
Activation of plasma kallikrein arginine esterase activity by kaolin resulted in peak activity at 1 min of incubation and a 50% reduction in activity at 5 min in normal plasma, and 30% reduction in the plasma of patients with hereditary angioneurotic edema who lacked the C1 inactivator. The peak esterolytic activity was inhibited by soybean trypsin inhibitor whereas the 5 min activity was resis...
متن کاملIntradiscal Injection of an Autologous Alpha-2-Macroglobulin (A2M) Concentrate Alleviates Back Pain in FAC-Positive Patients
Objectives: A cartilage degradation product, the Fibronectin-Aggrecan complex (FAC), has been identified in patients with degenerative disc disease (DDD). Alpha-2-macroglobulin (A2M) can prevent the formation of the G3 domain of aggrecan, reducing the fibronectin-aggrecan G3 complex and therefore may be an efficacious treatment. The present study was designed to determine a. The ability of auto...
متن کاملAlpha-2-Macroglobulin: A Physiological Guardian
Alpha macroglobulins are large glycoproteins which are present in the body fluids of both invertebrates and vertebrates. Alpha-2macroglobulin (a2M), a key member of alpha macroglobulin superfamily, is a high-molecular weight homotetrameric glycoprotein. a2Mhasmany diversified and complex functions, but it is primarily known by its ability to inhibit a broad spectrumof proteaseswithout the direc...
متن کاملAlpha 2 macroglobulin state in acute pancreatitis. Raised values of alpha 2 macroglobulin-protease complexes in severe and mild attacks.
Plasma values of C reactive protein, alpha 1 proteinase inhibitor, alpha 2 macroglobulin, and complexed alpha 2 macroglobulin have been determined in serial samples from 27 patients with acute pancreatitis. Complexed alpha 2 macroglobulin was measured by a novel enzyme linked immunosorbent assay with a monoclonal antibody specific for the complexed form. Patients with severe illness had lower c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2020
ISSN: 1768-3262
DOI: 10.4267/2042/70878